The Unwinder is reader-supported, meaning we may earn an affiliate commission if you buy through a link from our site.


What’s The Best Lion’s Mane Supplement? Our Top Picks For Lion’s Mane Mushroom Elixir, Lion’s Mane Mushroom Tea, And More

Lion’s mane, also known as yamabushitake, is an edible mushroom that shows promise as a cognitive enhancer, mood booster, and immunomodulator. This is due to its active ingredients including beta-glucans and antioxidants.

Lion’s mane was traditionally used as a tea, but is now widely available in capsules. Consumers describe the taste of lion’s mane tea as similar to crab or lobster, though this has since been disguised in coffee, flavored teas and capsules.

In this article we’ll explain where to buy lion’s mane mushroom, the best lion’s mane supplements, and why you should be interested in lion’s mane. 

Lion’s Mane Benefits

One of lion’s mane’s key active compounds, beta-glucans, has several types of biological activity ー each of which is beneficial for a different bodily process. In addition to these effects, lion’s mane can also improve several mental health parameters. For example, a study found that after taking lion’s mane for 4 weeks, subjects had reduced depression and anxiety symptoms.

Beta-glucans are a class of neuroprotective compounds which clinicians believe can prevent cognitive decline. In rats induced with dementia, lion’s mane prevented impairments in short-term recognition. In patients with mild cognitive impairment, a placebo-controlled double-blind trial successfully demonstrated that lion’s mane can improve cognition – suggesting its promise for neurodegenerative disorders like dementia and Alzheimer’s.

To reverse cognitive impairment, redeveloping neural circuits in the brain is one potential mechanism. An in vitro study showed that NGF (nerve growth factor) ー a neurotrophic factor found in the brain that is boosted by lion’s mane ー enhances neurogenesis, further demonstrating lion’s mane potential role in treating cognitive disorders.

Different compounds in lion’s mane can suppress or enhance immune activity and inflammation. In one study, lion’s mane suppressed pro-inflammatory factors in vitro. In another, beta-glucans upregulated the innate immune response. It’s unclear yet what this means for immune function or what the best use case would be.

Boosting the immune system may have anti-cancer benefits though. In mice, a study found that lion’s mane inhibits cancer metastasis, specifically for colon cancer spreading to the lungs. However, there are different types of cancer and lion’s mane might interact with other drugs so for now these results only suggest lion’s mane’s future potential.

Human studies have used 2-3 grams of whole lion’s mane powder daily. The most common dose is 1000 mg 2-3 times a day, for 2-3 grams a day total. It’s still too early for the optimal dosage to be determined.  The best way to take lion’s mane mushroom is generally in capsule form, for convenience.  

The only side effects we are aware of is itchy skin which often occurs due to an increase in nerve growth factor that exacerbates atopic dermatitis during use. If this causes discomfort, you should stop taking lion’s mane. Sometimes you can also develop itchy skin if you’re allergic to lion’s mane mushrooms – if this happens, again stop using it right away.

Lion’s Mane Reviews

Real Mushrooms Lion’s Mane Capsules

Best Lion’s Mane Supplement

Double Wood Lion’s Mane Capsules

Double Wood Lion’s Mane Capsules contain 500mg of whole fruiting body per capsule. Fruiting bodies are the reproductive structures of mushrooms and contain a higher amount of active ingredients, including beta-glucans. Double Wood sources their lion’s mane from California mushroom farms.

We recommend taking 2 capsules twice a day for 1 gram of lion’s mane a day. Even though this is half the dosage that clinical trials have used, users have noticed significant improvements in memory and cognition.

Real Mushrooms Lion’s Mane Capsules

Best High Dose Lion’s Mane Capsules

Real Mushrooms Lion’s Mane Capsules

Real Mushrooms Lion’s Mane Capsules contain non-GMO, organic lion’s mane mushrooms whose fruiting bodies are hot water extracted for a pure, chemical-free product. Their capsules also don’t contain grain fillers  – a common issue with other mushroom capsules – that are harder to digest and may even trigger grain-associated allergies.

If you’re looking for a higher dose, Real Mushrooms has the best lion’s mane supplement for you. Each serving provides 1 gram per 2 capsules – they recommend taking 2 capsules 2-3 times a day. This follows on from the dosage used in human clinical trials. Importantly, this product guarantees at least 25% beta-glucans for high potency as beta-glucans levels are measured by third-party testers.

Real Mushrooms Lion’s Mane Powder

Best Lion’s Mane Mushroom Powder

Real Mushrooms Lion’s Mane Powder

Like the capsules, Real Mushrooms Lion’s Mane powder is dosed the same at 1 gram per ½ teaspoon. Again, Real Mushrooms promises that each serving has a potency of at least 25% beta-glucans. Their mushrooms are organic and hand-picked to make sure you are receiving the best fruiting bodies for consumption.

Traditionally, lion’s mane powder was brewed in a tea, but most people who have tried it say it tastes better mixed with coffee.

Teecino Lion’s Mane Tea With Rhodiola

Best Lion’s Mane Mushroom Tea

Teecino Lion’s Mane Tea With Rhodiola

Teeccino Lion’s Mane Mushroom Tea mixes 300mg of lion’s mane with 300mg of rhodiola rosea in each packet, ready for you to brew a tasty lion’s mane mushroom elixir. 300mg is a low dose of lion’s mane, but probably not insignificant enough to notice effects.

Rhodiola is an adaptogenic herb which simultaneously helps the body react to stress and reduces anxiety. The combination of lion’s mane with rhodiola will help uplift your mood, though the boost to neurogenesis will likely be minimal.

Four Sigmatic Mushroom Coffee With Lion’s Mane And Chaga

Best Lion’s Mane Mushroom Coffee

Four Sigmatic Mushroom Coffee With Lion’s Mane And Chaga

Four Sigmatic Mushroom Coffee is great if you’re looking for creative focus and improved cognitive function. Four Sigmatic’s mushrooms are USDA-certified organic, extracted from wild forests and mushroom farms. Simply brew this coffee in your preferred fashion and drink. Users love this coffee because it actually tastes like coffee; you wouldn’t guess from the flavor that it contains mushrooms.

This coffee is dosed low at 250 mg each of lion’s mane and chaga.  However the combination of the two with caffeine can act as a mild cognitive and mood enhancer. Again, probably not a big long-term neurogenesis booster but great in the short-term.

Maui Herbs Lion’s Mane Tincture

Best Lion’s Mane Mushroom Elixir

Maui Herbs Lion’s Mane Tincture

Maui Herbs Lion’s Mane Tincture extract is a convenient way to boost cognitive health on the move. It contains about 233 mg of lion’s mane per ml, meaning you’ll want to take several droppers a day to reach an effective dosage. Users find this tincture very potent; anecdotally, they experienced a clarified mind following regular consumption.

Maui Herbs’ tincture is ideal for mixing with coffee, tea, or whatever your beverage of choice is. This tincture is particularly good for mixing with cold beverages, since powder won’t dissolve well in those.

Editor’s note: we are regularly updating this review. If you see any problems, weird interpretations of the data, or just want to say hi, please reach out to hello@the-unwinder.com.

About the author

Lucy is a UK-based freelance writer focusing on biological content, whether it may involve animal biology or health and well being. Having achieved a First Class Zoology degree at the University of Bristol, Lucy has a diverse knowledge base and enjoys writing for others. Lucy is also a medical student in London who enjoys, in her free time, weight lifting at the gym or hiking along precarious routes in the great outdoors.

Leave a Reply

Your email address will not be published. Required fields are marked *