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The 6 Best Ashwagandha Brands Containing Withanolides That We Really Like

Ashwagandha, Withanolides: The 6 Best Ashwagandha Products With A Sufficient Amount Of Withanolides—At A Glance

Our Top Pick

Nootropics Depot Shoden® Ashwagandha Extract Capsules

This product soars to the top of our list due to having a concentration of 35% withanolides.

Best Ashwagandha Gummies

Goli Nutrition Ashwagandha Gummies

Goli Nutrition is the leader in the gummy vitamin industry for ashwagandha gummies. Each gummy has a withanolide content percentage of 0.17, however, if you use gravimetric analysis (which is what every other brand uses) the concentration is found to be nearly 15%!

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Toniiq Ashwagandha

Another Great Value Product With Potency

Toniiq Ashwagandha

Toniiq Ashwagandha offers one of the most potent ashwagandha supplements on the market, with 10% withanolides.

Editor’s note on 5/28/22: This product is currently out of stock. We will update this review when it becomes available again.

Great Value

Daily Nutra KSM-66 Ashwagandha

Daily Nutra partners with KSM-66 Ashwagandha to produce a full-spectrum root extract with 5% withanolides.

Tribe Organics Ashwagandha

Trustworthy, Specialist Brand

Tribe Organic Ashwagandha

We like this ashwagandha supplement because of the brand’s clear transparency with ingredients, the extraction process, and peer-reviewed support.

Best Organic Ashwagandha

Garden Of Life Ashwagandha

Garden of Life is well known for its organic, whole-food-derived products. This product contains organic ashwagandha root extract that’s standardized to 5% withanolides along with organic fermented ginger root and a probiotic blend to support digestion.

You may have decided that it was finally time to start using an adaptogen to relieve stress, improve your sleep, or even support your fertility. If you’ve done enough digging, then you probably realized that ashwagandha is one of the best adaptogens available to date and that it’s been clinically validated for its wide range of health benefits.

While there are a fair amount of ashwagandha supplements available via D2C brands as well as on Amazon, there’s one major feature that you need to keep your eye out for – withanolides. You might have discovered an amazing all-natural, possibly even organic, ashwagandha supplement, but if its withanolides composition is too low (or not listed at all for that matter) you’re wasting your time and money on that product and should look elsewhere.

Here, I’ll take a deep dive into the topic of ashwagandha withanolides explain clearly why you need to pay attention to them and how they can make a huge difference towards your intended health goal. I’ll also review the best ashwagandha brands containing at least 3% withanolides content, but you may be shocked at how high the composition of withanolides is for the best brand of ashwagandha.

TL;DR: Why Withanolides Are Crucial To Getting The Best Ashwagandha Supplement

  • Withanolides are the active ingredient in ashwagandha, a popular adaptogen that recently hit the DTC market.
  • Many ashwagandha brands fail to list how much withanolides content is in their ashwagandha supplements. 
  • Instead, some products will list ultra-high milligram counts while failing to mention withanolides content at all. 
  • If you don’t see a percentage of withanolides on the ashwagandha supplement or there are no credible certificates, then it’s probably not worth your money.

What are withanolides?

Withanolides are the active ingredient in ashwagandha, a popular adaptogen sold in supplement form. Ashwagandha’s benefits work best when it includes a high concentration of withanolides, which research shows can be beneficial in inhibiting tumor growth and fighting inflammation.  

Let’s back up. Ashwagandha is an ancient medicinal herb that provides benefits to your body and brain over time. Its botanical name is Withania somnifera as it comes from a small shrub with yellow leaves that’s native to India. The powder extracted from its roots and leaves supplies healing benefits such as reducing stress and cortisol levels. And within the powder, there should be a high concentration of withanolides—the active ingredient that gives ashwagandha its ability to help the body with mental and physical stress. 

Withanolides can also be called steroidal lactones, which are the biologically active chemical constituents of Withania somnifera. The root of the plant is believed to account for its exceptional medicinal properties because it contains a high concentration of bioactive compounds that reduce inflammation and stress and modulate metabolic processes. It’s important to look for withanolide potency in ashwagandha supplements because the withanolide concentration dictates the strength of its effects. But we’ll get to that in a bit.  

Withanolides Benefits

Withanolides are steroidal, meaning they have a physiological action. There are about 40 withanolides in Withania somnifera, each with a different neurochemical effect on the body. You’ll get a different mix of withanolides depending on whether you extract from the root or the plant’s leaf.  

The following are 3 of the most common withanolides and their specific health benefits.

Withanolide A

Withanolide A, extracted from the root, has been tested on mice to show its role in stress management, including immune function regulation. When it’s extracted from the leaf, it has been shown to have anticarcinogenic effects in human cells, meaning it may inhibit the development of cancer. 

Withaferin A

Withaferin A, as an active compound in ashwagandha, has been shown to have significant anti-stress activity. It’s also studied for its anti-cancer properties. 


And then there’s Glycowithanolide, which can be extracted from the root or the whole plant and plays a role in anti-stress activity and may help to reverse the cognitive defects of Alzheimer’s disease. 

Withanolides And Ashwagandha

Ashwagandha contains withanolides and includes alkaloids, salts, steroidal lactones, and flavonoids. Research shows that the withanolides help to regulate metabolic hormone levels. It is beneficial in reducing stress and cortisol levels, but it may also mildly enhance sprinting capacity, increase motivation, and speed up one’s metabolism via increased thyroid hormone secretion over time. 

Purchasing ashwagandha based on withanolide content will actually make the supplement worth your while. Here’s a little extra info to help you learn why.

Are Withanolides Only Found In Ashwagandha?

You can find Withanolides in plants in the Solanaceous family. There are about 40 ashwagandha withanolides in the roots and leaves of Withania somnifera. The different chemical compounds of ashwagandha work together to produce benefits that are believed to reduce inflammation, reduce stress and anxiety, increase muscle mass, and contain anti-cancer properties. 

Why Does Withanolide Content Differ By Ashwagandha Product?

Withanolides don’t make up the entire ashwagandha supplement. There are other chemical constituents involved, such as alkaloids, steroidal lactones, salts, and flavonoids. Depending on the product or brand, you’re going to find different concentrations of withanolides in ashwagandha. 

Withanolide content also depends on where the ashwagandha is extracted from in the Withania somnifera plant (root or leaf). For instance, a product like Daily Nutra KSM-66 Ashwagandha is extracted and standardized from the root, creating a safe, low-toxicity form of ashwagandha. When a product has a high withanolide content, such as Toniiq Ashwagandha, the extract is likely to be from the whole plant.

As mentioned earlier, withanolides interact with the body in different ways depending on where they’re extracted from in the Withania somnifera plant. The leaves have different concentrations and types of withanolides than the root. For instance, leaf extracts contain high levels of Withaferin A, which acts as a cytotoxic. But the root has high levels of Withanolide A, which helps reduce stress and promote immune function. It’s important to read the labels of ashwagandha products so you know where it’s extracted from and what benefits you’re getting out of the active ingredients. 

Where Can You Find Withanolide Content Listed In Any Particular Ashwagandha Supplement?

After all this talk about withanolides, of course, we’re going to give you the tools to find the withanolide content listed on an ashwagandha supplement. It’s pretty simple. If you’re purchasing a product online, zoom over the “supplement facts” label of the ashwagandha product. Under the words “ashwagandha extract” you should see a percentage of withanolides. 

In some cases, it might also be listed on the front label  However, you should still read the “supplement facts” on the back for more detail.

The label should also tell you where the supplement is extracted from (roots or leaves), and the product should be accompanied with a certificate of analysis so that you know the source was thoroughly examined before purchase.

If you don’t see a percentage of withanolides on the ashwagandha supplement or there are no credible certificates, take the product out of your cart. It’s not worth your money. Read those labels! 

How Much Withanolide Content Should You Look For In Ashwagandha?

You want a high(ish) concentration of withanolides in ashwagandha because it’s the active ingredient that provides worthwhile, long-term benefits. So an increase in withanolide concentration dictates the strength of its effects. 

Ashwagandha dosage is usually in milligrams—the most common dose is about 300 mg-600 mg per capsule. But remember, it’s not just the amount of ashwagandha in a product that’s important, it’s the potency (or percentage of withanolides) of the ashwagandha that makes the difference. You want to look for about 2.5%-10% withanolides in your ashwagandha product, or about 10-50 milligrams of them, depending on the benefits you want to get out of the supplement.

Now that we understand why withanolide content is essential when choosing an ashwagandha product, we reviewed four supplements that are actually worth your money. 

It’s important to note that although ashwagandha is safe for most people, certain individuals (women who are pregnant or breastfeeding or those with an autoimmune disease) should consult their healthcare provider before taking it. 

6 Of The Best Ashwagandha Supplements: Brands Of Ashwagandha With Highest Withanolides

Best Ashwagandha Capsules

Nootropics Depot Shoden® Ashwagandha Extract Capsules

If you’re looking for Ashwagandha capsules with the highest concentration of withanolides, then Nootropics Depot has the product for you.

Each capsule provides 120 mg of concentration of Shoden® Ashwagandha Extract that has a concentration of 35% withanolides – this is incredibly hard to come across!

It is recommended to take one capsule up to two times daily.

Best Ashwagandha Gummies

Goli Ashwagandha Gummies

Goli reports that each gummy has a withanolide content percentage of 0.17, but that most other Ashwagandha labels use a less precise method of measurement called gravimetric analysis. If you go by this method, the concentration is found to be nearly 15%!

These gummies are available in berry flavor and each serving of 2 gummies provides 300 mg of KSM-66 Ashwagandha along with 25 mcg of vitamin D2.

Contrary to many standard brands, Goli does not use excessive sugar in its formulation and each serving only contains 4 g of sugar total. On top of that, its gummies are gelatin-free and vegan-friendly since they’re made with pectin.

It’s recommended to take 2 gummies, twice daily for best results.

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Toniiq Ashwagandha

Best value and highest potency

Toniiq Ashwagandha

10% withanolides

Toniq Ashwagandha offers one of the most potent ashwagandha supplements on the market, with 10% withanolides. The powder is combined with black pepper extract to increase its bioavailability.

Toniiq Ashwagandha root is grown naturally and harvested from the foothills of Central India and then produced in a GMP-certified and NSF-approved manufacturing facility in Miami, Florida. Each batch is tested for solvent residues, heavy metals, and toxins both during and after manufacturing.

The recommended dose of two capsules (1,300mg) provides the equivalent of 15 generic ashwagandha capsules. At around $17 for 90 capsules, this product is reasonably priced, potent, and vegan, which is well-rounded for an ashwagandha supplement.

Editor’s note on 5/28/22: This product is currently out of stock. We will update this review when it becomes available again.

Great value

Daily Nutra KSM-66 Ashwagandha

5% withanolides

Daily Nutra KSM-66 Ashwagandha is a transparent brand that delivers high potency active ingredients in each capsule. Ixoreal Inc., the developer of KSM-66 Ashwagandha, is the industry leader in clinical trials investigating the effectiveness of ashwagandha. 

This particular product has undergone 12 clinical studies that follow gold standards of substantiation: randomized, double-blind, placebo-controlled designs. While it’s not vegan, this all-natural formula is completely free from fillers, preservatives, or synthetics.

Customer reviews of Daily Nutra KSM-66 Ashwagandha are positive, with people recommending it for reducing anxiety and balancing hormones.

Daily Nutra KSM-66 Ashwagandha is a full-spectrum root extract with 5% withanolides and each capsule contains 600mg KSM-66 Ashwagandha. At $30 for 90 capsules (600mg per capsule), it’s also a great value.

Tribe Organics Ashwagandha

Great Ingredients

Tribe Organics KSM-66 Ashwagandha

5% withanolides

Tribe Organics KSM-66 Ashwagandha is a root-only extract with a balanced and high concentration of withanolides. Over time, these capsules are meant to promote less stress and anxiety and enhance awareness, support hormone balance, and regulate sleep. 

This ashwagandha supplement is produced using an extraction process based on “Green-Chemistry” principles, meaning it’s made without using alcohol or other chemical solvents. Tribe Organics KSM-66 Ashwagandha claims to have the highest number of certifications of all ashwagandha extracts available on the market today.

It’s recommended to take 300 mg capsules twice daily over eight weeks to experience results. At just under $25 for 120 capsules (300mg per capsule), we find that it also provides great value for a product with high potency.

Best Organic Ashwagandha

Garden Of Life Ashwagandha

5% withanolides

Garden of Life is well known for its organic, whole-food-derived products. It combines organic ashwagandha with organic fermented ginger and a probiotic blend to support a healthy stress response and to optimize digestion.

It’s recommended to take 1 600 mg tablet once daily for best results.

Looking for more options? Check out this article.

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Editor’s note: we are regularly updating this review. If you see any problems, weird interpretations of the data, or just want to say hi, please reach out to

About the author

Marina is a freelance writer who's written for Business Insider, Thrillist, Fodor's Travel, and TripAdvisor. She covers a variety of topics including travel, health, business, and lifestyle. You can follow her on Twitter
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