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If You Want The Best CBD For Sleep, Combine It With These 2 Natural Supplements

Given what we know about the chemical mechanisms behind sleep and CBD, it makes sense to take a multi-pronged approach to supplementing for sleep. That is, instead of buying one CBD oil for insomnia, or other CBD products for sleep, we think it’s more effective to combine CBD with both melatonin and ashwagandha to make a ‘CBD sleep stack’. We believe this will work better for your sleep than CBD, ashwagandha, or melatonin alone. In this review, we explain why, then give you some recommendations for what to buy.

What’s the best CBD for insomnia? How much CBD for sleep is the right amount? CBD is commonly recommended as a sleep aid, and yet very few CBD companies will bother to explain why it’s effective or how it works. Some provide dosing guides, but even then, they rarely explain where those guidelines are coming from.

So understandably there’s a lot of confusion about why CBD works, or even whether it does. And to make matters worse, a lot of the studies on CBD use doses much higher than people typically use in real life.

In this article we’ll explain the chemical pathways involved in sleep, and how CBD affects them. Then we’ll tell you exactly how to incorporate CBD into a highly effective “stack” of sleep supplements that target every chemical pathway involved in sleep.

The Various Chemical Pathways Of Sleep

There are many, many chemical pathways involved in sleep, but there are three main ones you need to know about.

Cortisol And Sleep

Cortisol is commonly known as the stress hormone, but that’s a major oversimplification. Cortisol raises alertness and physiological arousal levels and helps to mobilize glucose to fuel activity. It is elevated first thing in the morning–it helps to wake you up–as well as during periods of physical and psychological stress, including exercise.

Accordingly, cortisol is normally low in the evening, and cortisol production is suppressed for at least the first 4 hours of sleep, but begins to rise again toward the end of sleep, in preparation for waking.

As you can guess, having elevated cortisol in the evening–whether due to stress or stimulant use–makes it harder to get to sleep and stay asleep. Furthermore, if you don’t get enough sleep one night, your cortisol levels will remain elevated the next night, and the nightly drop in cortisol will be delayed an hour or more. So sleep deprivation can create a cortisol-driven vicious cycle from which it can take several days to break out.

Melatonin And Sleep

Melatonin is commonly known as the sleep chemical, as it is the one neurotransmitter whose function relates primarily (though by no means entirely) to sleep.

It is produced from serotonin, the brain’s main happiness/relaxation neurotransmitter, which in turn is produced from 5-HTP which is made from the amino acid tryptophan.

Melatonin is the primary neurotransmitter responsible for sleep onset. Accordingly, you need more of it during the early phases of sleep, and even before you go to sleep. That said, it does appear to also play a role in sleep maintenance and quality, at least during the earlier phases of sleep.

Taking a melatonin supplement consistently speeds up sleep onset, with a moderate effect size on average. It also significantly improves sleep quality and total sleep time, but these effects were less consistent and smaller on average.

Cortisol increases serotonin uptake in brain cells. This can be misleading if you don’t know how neurotransmitters work; it doesn’t mean that cortisol increases serotonin production or usage. Quite the opposite in fact! It means that cortisol causes serotonin to be re-absorbed and effectively placed into storage for later, lowering serotonin levels for the time being.

In other words, cortisol prevents relaxation and melatonin production.That said, higher cortisol levels earlier in the day can save your brain’s serotonin stores for later. Again, cortisol isn’t a bad hormone; it’s just bad to have it elevated all the time, especially at night.

GABA And Sleep

Gamma-Aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in mammalian nervous systems.

GABA enhances the conversion of serotonin into melatonin in rats. This hasn’t yet been demonstrated in humans, but since the chemicals are the same then in principle they should interact the same way.

Accordingly, taking GABA improves sleep latency and sleep efficacy in insomnia patients. However, GABA only crosses the blood-brain barrier in very small quantities, so the patients had to make up for that by taking a very large quantity of it– 300 mg. 10% of patients experienced adverse effects.

Stress also reduces GABA levels, so you can increase GABA production by de-stressing. All things considered, you’d rather do this than take exogenous GABA, because it’s cheaper and less likely to have side effects.

To Recap, Here’s What You Want For Optimal Sleep

  • Cortisol levels to be high in the morning, but as low as possible starting 2-3 hours before sleep onset until 1-2 hours before waking
  • Serotonin levels to be high for a couple hours before bed and a couple hours after
  • Melatonin levels to be high 30 minutes or so before sleep and continuing for 4-5 hours after that
  • GABA levels to be high in the evening and throughout the night until shortly before waking

So How Much Does CBD Help With Sleep?

CBD obviously isn’t a naturally-occurring neurotransmitter–so how does it interact with them?

It is well-established at this point that CBD reduces anxiety levels, which in turn aids sleep. Logically you would expect this to be accompanied by a decrease in cortisol levels, although that has not been directly measured.

One study did look at the effect of CBD early in the morning on cortisol. It found that morning CBD delays the natural diurnal reduction in cortisol levels, yet at the same time has a sedative effect. This supports that elevated cortisol is only energizing for a short period, but doesn’t make clear CBD’s effects on evening cortisol levels.

Another exploratory study found that CBD raises GABA levels in neurotypical human brains, but lowers them in people with autistic spectrum disorder.

Marijuana has been found to increase melatonin production in inexperienced users, but the effects in experienced users are more mixed and not entirely positive. The effects of CBD in particular on melatonin have not been directly studied.

However, at least one study has found that CBD increases the production of serotonin, a precursor to melatonin.

In short, some studies have shown that CBD is helpful for supporting healthy sleep, particularly in people with anxiety issues. Mechanistically, CBD likely supports sleep via several chemical pathways, but its effects are probably not very powerful within any given pathway.

In short, CBD is a valuable adjunct to a sleep supplement stack, but not likely to be a silver bullet for better sleep, with the possible exception of some people who have moderate to severe anxiety issues.

Try This CBD-Based Sleep Stack

Given what we know about the chemical mechanisms behind sleep, it makes sense to take a multi-pronged approach to supplementing for sleep.

1. CBD

First, CBD. It reduces stress, increases GABA and serotonin production, and has been shown to improve sleep quality.

Since you want all those benefits to last for hours, it makes the most sense to take CBD in edible form, which will slow absorption and spread out the effect over a longer period of time.

CBD dosages vary widely—most studies use 300-600 mg, but anecdotally, people usually find lower doses to be effective. And since you’ll be combining it with other supplements, you don’t necessarily need a high dosage. Somewhere in the 20-100 mg range is probably what you want; start slow and work your way up.

2. Melatonin

Second, melatonin. It works, it’s safe, it’s cheap, and it’s probably the most effective supplement for sleep induction.

Most melatonin supplements are dosed higher than they need to be though. It only takes .3 mg of melatonin to raise the brain’s melatonin levels to the level required for sleep. Higher doses–.5 mg and above–induce a phase-shift effect, meaning they can move your circadian rhythm forward. That makes higher doses useful for resetting your internal clock to recover from, say, jet lag or a period of sleep disruption. But for daily use, .3 to .5 mg is all you need.

That said, since melatonin also affects sleep quality, there’s an argument to be made for having a slightly higher dosage if it’s in extended-release form.

3. Ashwagandha

Finally, ashwagandha is an excellent adjunct to any sleep stack, but it’s particularly effective for people who find stress getting in the way of their ability to sleep. It also combines perfectly with melatonin and CBD.

Ashwagandha acts as an anxiolytic, decreasing cortisol secretion as well as subjective stress, as well as improving sleep quality. It is sedating at high doses but non-drowsy at lower doses, and appears to act as an adaptogen.

Ashwagandha root extract also mimics the effects of GABA, but without increasing GABA production per se. This means it has great synergy with something that does increase GABA production, like CBD.

Ashwagandha does not directly increase melatonin production. However, as you saw earlier, anything that decreases cortisol and increases GABA (or mimics it, in this case) will enable the brain to produce more melatonin, without forcing it to do so.

The effective dosage for ashwagandha usually ranges from 250 to 650 mg, with the upper half of that range being sedating and only advisable at night. Lower doses, around 50-200 mg, can sometimes be effective at enhancing the effect of other anxiolytics.

As for timing—how to use CBD for sleep—CBD should be taken around two hours before bed if in edible form, or one hour before bed if inhaled. Ashwagandha should be taken one hour before bed, and melatonin a half hour before bed. You don’t need to be precise with these times, but you will get the best results if you follow them at least approximately.

CBD and ashwagandha can also be taken during the day, with food, as non-sedating anxiolytics. In that case you’d want low doses of each—around 10 mg of CBD and 100-200 mg of ashwagandha, twice a day.

Building Your CBD Sleep Stack

To build a full sleep stack, you’ll need one CBD product, one melatonin supplement, and one ashwagandha supplement. Note that because you’re combining multiple supplements, you’re better off starting with low doses of each and working your way up.

Our CBD for sleep stack recommendation

CBDFx 300 mg CBD Gummies + NOW Liquid Melatonin + Tribe Organics KSM-66 Ashwagandha

Stack allows for optimal dosing with authentic supplements

Our CBD for sleep stack recommendation is:

  • CBDFx gummies: these 5 mg gummies are perfect for getting a precise dose of CBD, however much or however little you want
  • NOW’s Liquid melatonin: these melatonin drops will, again, allow you to precisely dose according to your nightly needs
  • Tribe Organics’ KSM-66 Ashwagandha has authentic ingredients that include withanolides and allow for a perfect dose right before bed—300 mg.

If you want to pick and choose between the various products, check out the recommendations below.

The Best CBD Gummies For Sleep

Gummies allow precise dosing

CBDfx 300 mg CBD Gummies

Mixed berry flavor

  • 5 mg per gummy, with a little sugar to aid flavor and absorption
  • Slow-absorbing
  • Gummy form allows precise dosing in 5 mg increments
  • 100% vegan

Best CBD Oil For Sleep

Best value

Kats Botanicals Natural CBD Oil

50 mg doses

  • Lowest price per mg
  • Most effective form for consuming higher (50+ mg) doses
  • Dosing is approximate rather than precise as with gummies
  • No added flavors– easy to mix with tea, hot chocolate, etc

The Best CBD Capsules For Sleep

Best for precise high dosing

Endoca High-Dose CBD Capsules

Super convenient

  • 50 mg per capsule
  • Best option for high doses with precise dosing
  • Easiest to travel with

Best Immediate-Release Melatonin

Adjustable dosing

NOW Foods Liquid Melatonin

2 to 3 drops nightly

  • Liquid form allows adjustable dosing
  • One of the few products that isn’t dosed too high for daily use
  • Take 2-3 drops most nights to get .3-.5 mg
  • Take 10-20 drops to reset your circadian rhythm, i.e. when jetlagged

Best Extended-Release Melatonin

Works throughout the night

Natrol 1 mg Time Release Melatonin

Helps you fall asleep and stay asleep

  • Use if you need help staying asleep, in addition to falling asleep
  • Dosage acceptable for daily use, given that it’s timed-release

Best Ashwagandha Extract

Great value

Tribe Organics 300 mg KSM-66 Ashwagandha

Uses KSM-66 ashwagandha

  • 300 mg per pill (note that the front says 600 mg, as the serving size is 2 pills)
  • 300 mg is perfect for use in a sleep stack; 600 mg should be reserved for pre-bed use without CBD, or those with high tolerance or high anxiety
  • 300 mg is also ideal for daytime use with food for many people.
  • Low cost per pill

Best Low-Dose Ashwagandha Extract

Best low dose

NatureMade 125 mg Ashwagandha Capsules

Combine with high dose of CBD

  • Ideal for daytime use by people who get drowsy easily
  • Ideal for combining with high doses of CBD

Editor’s note: if you want to take your sleep game a bit further, you should start thinking about the effects of blue light on your Circadian rhythm. You might want to consider buying products such as blue light glasses or tinted lightbulbs that help you manage your blue light exposure. To learn more, check out our review of the science behind sleep and blue light.

We discuss CBD and ashwagandha extensively in this review. If if you’re interested in exploring more about these supplements, check out the following:

About the author

John Fawkes is the Managing Editor of The Unwinder. John is an NSCA-certified personal trainer and Precision Nutrition-certified nutritional counselor who has been featured on over two dozen websites and podcasts. He works with clients in Los Angeles and online, and can be reached on Instagram and Twitter.
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