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Our Reviews Of The Best Nootropics For Anxiety, Depression, Sleep, And Brain Fog

Best Nootropics For Anxiety At A Glance

Best Nootropic For Anxiety

N-Acetyl L-Cysteine (NAC) By Double Wood Supplements

N-acetylcysteine (NAC) is an antioxidant that increases levels of the body’s primary antioxidant, glutathione. Glutathione deficiency has been linked to some mental disorders, particularly anxiety and anxiety-related disorders.

It’s quite difficult to find reliable vendors for NAC as Amazon and other major suppliers have stopped offering NAC completely, however, Double Wood Supplements is one of the few brands we trust that still sells this supplement.

Best Nootropic For Depression

5-HTP By Toniq

L-5-hydroxytryptophan (5-HTP) is a complex component that’s vital in neurologic and metabolic processes. A study at the University of Turin used the psychological effects of 5-HTP in both animal and human clinical trials. Results show that 5-HTP has a psychological role in treating depression, anxiety, panic disorders, sleep disorders, obesity, myoclonus, and serotonin syndrome.

Best Nootropic For Motivation

Mucuna Pruriens Extract By Double Wood Supplements

Dopamine is produced by our bodies, but it can also be obtained through nootropics. Lenovo (L-dopa) is an essential amino acid that the body uses to produce dopamine.

The discovery of L-dopa was a breakthrough in the treatment of Parkinson’s disease caused by dopamine depletion. Administering L-dopa tends to restore lost dopamine and can also reverse the patient’s symptoms.

Best Nootropic For Sleep

L-Theanine By Double Wood

L-theanine has demonstrated incredible results towards improving NREM sleep, especially in individuals with ADHD. It can also be used to promote relaxation throughout the day as well.

Best Nootropic For Focus

L-Tyrosine By Thorne

L-Tyrosine is the best nootropic for brain fog. Studies have shown its ability to increase focus, enhance memory and promote critical thinking.

Nootropics, also known as brain-enhancing drugs, are dietary supplements commonly used to improve cognitive ability and mental health. An increasing number of people are using nootropics to excel in their careers and help treat their mental health problems, such as anxiety, sleep deprivation, lack of motivation, depression, and brain fog.

There are numerous nootropics available, ranging from synthetic to natural compounds. Each nootropic has its own unique benefits and combining nootropics allows you to achieve the best results possible.

The mechanism of the nootropics system is dependent upon the compound. In general, nootropics influence cellular processes including neuronal metabolism, cerebral oxygenation, and neurotransmitter function. As a result, their use improves cognitive functions like memory, motivation, creativity, and attention.

Best Nootropics For Anxiety, Depression, Sleep, And Brain Fog

A nootropic stack is a mixture of two or more nootropic compounds that provide multiple health benefits. It contains numerous combinations of natural nootropics, some of which are combined with racetams drugs. 

You can create nootropic stacks independently rather than purchase random stack bundles without knowing their composition or benefits. You can mix natural and synthetic nootropics, or even both.

With an increasing number of natural and synthetic nootropics on the market, it may be challenging to choose the best one. If you don’t know which supplement is best for your condition, you might end up purchasing the wrong nootropic.

To help you better understand nootropic’s capabilities, I will discuss what type of nootropic best suits a particular condition and the best product available for your convenience. 

Nootropics For Anxiety

Several studies have found that nootropics can aid the treatment of anxiety. 

N-acetylcysteine (NAC) is an antioxidant that increases levels of the body’s primary antioxidant, glutathione. Glutathione deficiency has been linked to some mental disorders, particularly anxiety and anxiety-related disorders. In one study, NAC was used to treat psychiatric disorders. The research summarized NAC’s ability to treat symptoms associated with various psychiatric disorders, including ADHD, anxiety, bipolar disorder, depression, obsessive-compulsive disorder, posttraumatic stress disorder, and schizophrenia.

Another nootropic, called L-theanine, can also be used as an anti-anxiety supplement. L-theanine is an amino acid found in green tea that has been shown to promote relaxation and ease. Most of its benefits are for treating sleeping disorders and anxiety.

Best Nootropic For Anxiety

N-Acetyl L-Cysteine (NAC) By Double Wood Supplements

Double Wood Supplements offers 210 capsules of NAC for $29.95. Each capsule contains 500 mg and it is recommended to start with 2 capsules per day for a few weeks and then increase your dosage to 4 capsules daily.

It’s quite difficult to find reliable vendors for NAC as Amazon and other major suppliers have stopped offering NAC completely, however, Double Wood Supplements is one of the few brands we trust that still sells this supplement.


Nootropics For Depression

There are numerous approaches to treating depression, but when it comes to dietary supplements, 5-HTP is the way to go. L-5-hydroxytryptophan (5-HTP) is a complex component that’s vital in neurologic and metabolic processes. A study at the University of Turin used the psychological effects of 5-HTP in both animal and human clinical trials. Results show that 5-HTP has a psychological role in treating depression, anxiety, panic disorders, sleep disorders, obesity, myoclonus, and serotonin syndrome.

NAC can also serve as an alternative treatment for depression. A clinical study showed that patients who were given NAC treatment improved their depressive symptoms. Aside from 5-HTP and NAC, there are also few indications that L-tyrosine can alleviate chronic stress, especially in patients who are affected by depression. In a related study where L-tyrosine was prescribed using an animal model, findings show that L-tyrosine plays a vital role in chronic stress management by improving the neuroendocrine network.

Best Nootropic For Depression

5-HTP By Toniq

Pure Nootropics offers 90 vegetarian capsules of 5-HTP for only $12.99. Each capsule provides 100 mg of pure 5-HTP.

It is recommended to 1 capsule daily and this supplement should not be used with other products that contain L-tryptophan or 5-HTP.


Nootropics For Motivation

You simply can’t get any task done without having some form of motivation. A decline in motivation means your body has less dopamine, making things uninteresting and undesirable. If you’re feeling unmotivated, you should consider taking nootropics to get back in the groove. 

Dopamine is produced by our bodies, but it can also be obtained through nootropics. Lenovo (L-dopa) is an essential amino acid that the body uses to produce dopamine. The discovery of L-dopa was a breakthrough in the treatment of Parkinson’s disease caused by dopamine depletion. Administering L-dopa tends to restore lost dopamine and can also reverse the patient’s symptoms.

Best Nootropic For Motivation

Mucuna Pruriens Extract By Double Wood Supplements

Double Wood Supplements offers 210 capsules of Mucuna Puriens extract per bottle. Each serving of 2 capsules provides 1,000 mg of 25:1 extract

It is recommended to take 2 capsules per day on an empty stomach and to not exceed 2,000 mg daily.

Each bottle costs $19.95, but if you subscribe then you’ll receive 15% off.


Nootropics For Sleep

People often use sleeping pills when they have trouble sleeping, but prescription pills can make a person drug dependent and require higher doses over time as their tolerance builds. As an alternative, you can use sleep-promoting nootropics like L-theanine. L-theanine has been studied for its efficacy in improving NREM sleep, including participants with ADHD. Because of its medical benefits, it is a considerable supplement that caters to anxiety and other psychiatric conditions.


5-HTP can also help people to fall asleep quickly. 5-HTP produces serotonin, which can then be converted to melatonin, a sleep-regulating hormone. A randomized controlled study using an amino acid preparation containing 5-HTP and gamma-aminobutyric acid (GABA) showed improved sleep quality for patients. 

Best Nootropic For Sleep

L-Theanine By Double Wood

This product comes with 120 capsules for $18.95. Each capsule contains 200mg of l-theanine and it is recommended for adults to take 1-2 capsules per day.

Dosages should be spaced out by at least 3-4 hours and consumers should not exceed the use of 8 capsules within 24 hours.

L-theanine works incredibly well for supporting deep sleep, but it may also be used towards promoting relaxation during times of stress and can be taken during the morning or afternoon as well.


Nootropics For Brain Fog

People suffering from brain fog are unable to think clearly. Brain fog is often due to different environmental and psychological factors that impair one’s ability to think. Lack of focus, mental fatigue, confusion, and slow thinking are all common symptoms.

L-tyrosine is one of many supplements available that can help with brain fog. People take l- tyrosine supplements for various reasons, the most common of which are brain conditions and medical benefits. According to reports, the personal benefits of l-tyrosine include increased alertness, focus, memory enhancement, motivation, and stamina. Most importantly, it reduces brain fog by encouraging critical thinking and cognitive flexibility.

Another study also proves the efficacy of l-theanine for brain-derived neurotrophic factor (BDNF), which is associated with brain fog. Clinical trials show that l-theanine is effective as an augmentation for antipsychotic therapy, promoting sharp and healthy cognition.

Best Nootropic For Brain Fog

L-Tyrosine By Thorne

L-Tyrosine by Thorne contains 90 capsules and is available for $22.00. Each capsule contains 500mg of l-tyrosine and it is recommended for adults to take 1 capsule three times daily.

If you’re looking for an alternative to stimulants for increasing focus and drive, then this supplement is exactly what you need.


Studies And Research You Can Read About Nootroopics For Anxiety, Depression, And More

Editor’s note: we are regularly updating this review. If you see any problems, weird interpretations of the data, or just want to say hi, please reach out to hello@the-unwinder.com.

Photo by Laurenz Kleinheider on Unsplash

About the author

Vella is a freelance content writer specializing in health and wellness, fitness, lifestyle, and CBD, among others. She worked as a journalist for a radio station before venturing into freelance writing. In her free time, she travels and explores nature and beaches. She can be reached via email at vellagonzaga@gmail.com.

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