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What To Know About Taking L-Tyrosine And Adderall Together

L-tyrosine is an amino acid that is a precursor for dopamine, a neurotransmitter linked to motivation, focus, and feelings of pleasure and reward. Adderall is a stimulant medication commonly prescribed to treat attention deficit hyperactivity disorder (ADHD) that works by increasing levels of dopamine and norepinephrine in the brain. Both L-tyrosine and Adderall aim to boost dopamine, so some people take them together, hoping for more significant benefits. However, several key things must be known before combining these two supplements.

How L-Tyrosine and Adderall Work

L-tyrosine is not dopamine itself but rather provides the raw materials for the body to produce more dopamine naturally. It crosses the blood-brain barrier and converts into L-DOPA by the tyrosine hydroxylase enzyme. L-DOPA is then further converted into dopamine. Increasing L-tyrosine levels through direct supplementation has been shown to increase dopamine levels in animal studies.

Adderall contains a mix of amphetamine salts that work as dopamine reuptake inhibitors. This means the amphetamines block the reabsorption of dopamine in the brain, resulting in higher concentrations of dopamine able to bind to receptors and transmit signals. Through this mechanism, Adderall has more potent and direct effects on boosting dopamine than L-tyrosine.

Potential Benefits of Combining Them

Some doctors and patients report better focus, concentration, and mood when combining L-tyrosine and Adderall together. The rationale is that providing more dopamine precursors through L-tyrosine supplementation may make even more dopamine available when taking Adderall. This stacked approach in theory, could enhance the cognitive-enhancing and mood-brightening effects of the medication.

However, current research has not found a clear benefit of adding L-tyrosine to amphetamine medications for ADHD. More studies are still needed to determine if this combination is advantageous.

Possible Side Effects and Safety Concerns

While L-tyrosine and Adderall are both generally well tolerated, combining them does come with potential side effects to be aware of:

  • Increased blood pressure – Both of these compounds can increase blood pressure, so stacking them may compound this effect. Those with hypertension should monitor their blood pressure closely.
  • Headaches – Headaches are possible with Adderall alone, and may be more likely when combined with L-tyrosine. Stay hydrated and limit caffeine intake.
  • Anxiety or restlessness – Some users report greater unease, anxiety, or being overly stimulated when stacking L-tyrosine with Adderall. Starting with lower doses of each can help.
  • Trouble sleeping – Insomnia is a common Adderall side effect. Adding L-tyrosine may worsen this, especially when taking later in the day. Take the stack earlier in the day.
  • Nausea – Stomach upset is possible with both supplements and may happen more frequently when combined. Take them with food.

It’s also wise to avoid taking extremely high doses of L-tyrosine to minimize potential toxicity. Doses above 200 mg/kg body weight are not recommended.

Interactions With Adderall

A few key supplement interactions with Adderall to keep in mind when stacking with L-tyrosine:

  • Vitamin C – Taking vitamin C can make Adderall less effective by increasing acidity and speeding up excretion. Avoid high dose vitamin C when taking Adderall.
  • Calcium – Calcium can also decrease amphetamine absorption—space out calcium supplements and Adderall dosing.
  • St. John’s Wort – This herbal supplement significantly reduces plasma concentrations of amphetamines through inducing the CYP3A4 liver enzyme. Avoid combining with Adderall.

Overall, L-tyrosine and Adderall have potential synergy for boosting dopamine levels and associated benefits like enhanced focus, mood, and motivation. However, side effects may be compounded when combining the two, so starting with conservative doses of each and monitoring closely is wise. Consult your doctor before mixing these supplements, especially if you are taking other medications or have underlying health conditions. More research is still needed on the optimal dosing, timing, and long-term safety of stacking L-tyrosine with Adderall or other stimulant medications.


  • L-tyrosine provides raw material to make dopamine, while Adderall prevents the reuptake of dopamine.
  • In theory, they can stack for greater dopamine levels and associated benefits.
  • However, increased side effects are possible when combining them.
  • Monitor blood pressure, sleep, and anxiety levels, and avoid specific supplement interactions.
  • More research is still needed on optimal dosing and long-term safety.
  • Talk to your doctor before mixing L-tyrosine and Adderall.
About the author

Holden Desalles is a journalist in the new wellness space, covering topics such as CBD, adaptogens, and nootropics. He was formerly a staff writer at the millennial lifestyle website Thought Catalog.

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