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Thinking Through TruBrain’s Multifaceted Nootropics Drinks

There are so many different nootropics supplements out there today, with many claiming unique benefits for cognitive enhancement and mental performance. And one such brand of nootropics supplements that we tested out was TruBrain.

We were intrigued by the fact that the TruBrain supplements were designed by UCLA neuroscientists, and ultimately wanted to see what benefits they had to offer. So, below we’ll discuss a little bit more about these TruBrain drinks, what’s included in them, and ultimately, how effective they are.

Background on TruBrain

TruBrain contains 6 different formulas designed to enhance cognitive performance and mental health. These personalized drinks come in 1oz “shot” forms and are designed to fit your unique needs. The six drinks they have are:

  • Mellow/Flow- designed for calm, balanced focus and stress reduction
  • Medium/Non-Caff- improve brain fog and cognitive function, without caffeine
  • Strong/Boost- designed to enhance cognitive performance and mental output
  • Extra Strong/Extra- designed to deliver extra strength support for maximal productivity and performance
  • Mushrooms- a blend of mushrooms and adaptogens for memory and focus
  • Sleep- designed to promote deep, restorative sleep

TruBrain Ingredients and Benefits

Obviously, the ingredient profile depends on which formula you’re looking at. But there are some similar ingredients across formulas. For example, Mellow, Medium, Strong, and Extra Strong (what I would call their four “main” nootropics) all contain:

  • Noopept (20mg)
  • Acelyl-L-Carnitine (500mg)
  • N-Acetyl Tyrosine (350mg)
  • Centrophenoxine (250mg)
  • Magnesium (as magnesium glycinate) (200mg)
  • L-Theanine (160mg)
  • Uridine Monophosphate (500mg)

There are also a few ingredients that make each of these unique. For example:

  • The Mellow/Flow variety has 50mg of added cannabidiol (hemp)
  • The Boost/Strong and Extra Strong varieties have 100mg of caffeine
  • And the Extra Strong variety also has 150mg of adrafinil

Noopept is a piracetam derivative that can increase BDNF and NGF while acting on acetylcholine and other neurotransmitters, thus boosting mood, alertness, and overall cognition.

Plus, carnitine and centrophenoxine help to increase levels of acetylcholine in the brain, which improves learning, focus, and memory.

We also liked to see tyrosine included, which can significantly boost dopamine and norepinephrine levels, thus boosting mood and alertness while fighting against stress, fatigue, and anxiety.

In these four, we also see magnesium glycinate, a chelated form of magnesium. This mineral can decrease stress and anxiety while also aiding many aspects of brain function, such as learning and memory.

Another staple ingredient included is theanine. This amino acid has been proven to increase GABA, serotonin, dopamine, and alpha waves in the brain; and it has been shown to reduce stress and anxiety while improving focus and concentration.

Adrafinil has been shown to increase norepinephrine and offers an overall stimulating affect, thereby improving alertness, attention, and energy.

Another unique ingredient is uridine monophosphate, which has been shown to boost some neurotransmitters (e.g. dopamine) while also stimulating the growth of new synapses in the brain.

Last but not least, we see caffeine in two of the products, which has long been known to enhance alertness, mood, and productivity, largely due to its ability to block adenosine and increase dopamine, serotonin, and norepinephrine. Caffeine is particularly beneficial when combined with theanine for a balanced, calm focus.

Now, the other varieties, Sleep and Mushrooms, are just different altogether and are more “specialized” nootropics. You can check out all the TruBrain products here.

TruBrain Sleep

The Sleep variety has:

  • Cannabidiol (50mg)
  • GABA (135mg)
  • Melatonin (5mg)
  • 5-HTP (10mg)

Cannabidiol has a number of effects on the brain and rest of the body and may be able to improve sleep due to its anxiolytic effects.

GABA is an inhibitory neurotransmitter, but supplemental GABA is not great at crossing the blood-brain barrier, so it typically isn’t very effective.

Melatonin is THEE classic sleep ingredient, since it’s the body’s primary sleep hormone. It has been shown to decrease sleep latency while improving overall sleep quality, but not as much in people with mental health disorders.

Finally, we see 5-HTP, which increases levels of serotonin in the brain and can improve mood while reducing stress and anxiety in some cases.

TruBrain Mushrooms

And the Mushrooms variety has:

  • Organic Lion’s Mane Extract (1,500mg)
  • Organic Rhodiola Extract (250mg)
  • Organic Guayusa Powder (250mg)
  • Organic Rosehip Extract (150mg)

Both Lion’s Mane and Rhodiola are adaptogens, so they help to normalize the stress response in the body, while fighting against fatigue, stress, and anxiety and enhancing energy levels.

Guayusa is a stimulant and also a pretty solid antioxidant, so it can improve focus, alertness, and attention.

Finally, rosehip is rich in antioxidants and can promote overall health and wellness.

Trying Out The Products

So, after viewing the ingredients, we could tell that the ingredients were generally well-researched and of a high-quality.

As a result, we were interested in trying out these products and seeing what they offer. So, we looked at just one of the first four (Boost/Strong), as well as the Mushrooms and Sleep varieties.


After taking the Boost/Strong formula, we definitely noticed some improvements in alertness, mood, and overall cognitive performance, as well as a little bit less stress and anxiety. It certainly wasn’t a cure-all, and there wasn’t anything very noticeable for memory, but it definitely helped to moderately improve daily functioning and performance. And there weren’t really any jitters from the caffeine (likely since there was theanine in there).

Based on the ingredient profiles of the other three “main” formulas, those should offer similar benefits here, with slight differences depending on which formula you choose. It all just depends on the level of energy you want; the very stimulant-sensitive should choose Mellow/Flow or Medium/Non-Caff, but for those who want a great jolt and boost, Extra Strong is your best bet.

Other Formulas

We also tried the Mushrooms and Sleep formulas, both of which delivered pretty good benefits too.


The Mushrooms formula definitely led to a decent increase in energy levels and focus, while also appearing to tone down stress and anxiety a bit, although this wasn’t greatly noticeable.


The Sleep formula also led to some benefits, particularly when taken on a regular basis. We noticed little bit less stress and anxiety, as well as an easier ability to stay asleep a little longer. And this led to feeling more refreshed the next day, which was nice!


Overall, we like the TruBrain products and think they are definitely effective as nootropics. They are pretty pricey though, and some of the ingredients ideally would have more research in humans. But overall, we noticed some key benefits from these supplements. Nothing that was miraculous, but, depending on the product, just a nice boost in focus, alertness, attention, energy, decreased stress and anxiety, or improved sleep. And sometimes that little boost is all you need. If you want to try them, you can do so here.

About the author

Jack Cincotta has a M.S. degree in Psychology. He is also a certified holistic health coach through AFPA and a board-certified holistic health practitioner through AADP. He often uses research-backed supplementation protocols for many of his clients to optimize results. In addition to running his holistic health practice, Jack also is an independent researcher and writer with a focus on health optimization content. Overall, he has been in the health and wellness industry for 3 years.

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